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The National Heart, Lung, and Blood Institute of the National Institutes of Health (NIH) has awarded a two-year grant to the American College of Cardiology Foundation (ACCF) in partnership with The Society of Thoracic Surgeons (STS) to study the comparative effectiveness of percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) surgery for the treatment of stable coronary artery disease.

The ASCERT™ (American College of Cardiology Foundation-The Society of Thoracic Surgeons Collaboration on the Comparative Effectiveness of Revascularization sTrategies) Study will compare catheter-based and surgery-based procedures using existing databases from the ACC and STS, as well as the Centers for Medicare and Medicaid Services’ 100% denominator file data, to examine long-term outcomes following revascularization.

"There remains considerable uncertainty about the best strategy between catheter-based and surgery-based approaches in patients requiring revascularization for coronary artery disease.  This collaboration between the ACC and STS will allow us to address this vital question.  By having available to us combined databases of over 10 million people, we will also be able to address concerns about choice in critical subgroups such as patients with other severe diseases and the elderly.  This grant will offer a model for how to pursue comparative effectiveness research using large clinical databases." -- Dr. William Weintraub, Principal Investigator

"The ASCERT™ Study has potential to be significant given the focus of the research (PCI versus CABG), the use of two of the most prominent clinical registries in the country, and the fact that collaboration between STS and ACC covers virtually the entire spectrum of adult cardiovascular disease.  To our knowledge no other cardiovascular research has approached the scope of this project,” -- Dr. Fred Edwards, Principal Investigator